regions of the Major

The etiology of RA is not completely known. There is evidence of the complex interrelation between environmental and genetic factors. The monozygotic twins have more than 30% concordance index for the development of RA and 80% of the white people with RA express the subtypes HLA-DR1 or DR4. This and other regions of the Major Histocompatibility Complex may confer susceptibility to more serious diseases through the presentation to CD4 + T cells of a specific arthrogenic peptide.

The joint lesion of rheumatoid arthritis begins with the proliferation of macrophages and fibroblasts in the synovial membrane, from the incident that triggers that reaction Keto Viante. The lymphocytes infiltrate the perivascular regions and the endothelial cells proliferate.